Clinical trials generate complex and standards-driven datasets that can slow down traditional data processing tools. This workshop introduces Polars, a cutting-edge Python DataFrame library engineered with a high-performance backend and the Apache Arrow columnar format for blazingly fast data manipulation. Attendees will learn how Polars lays the foundation for the pharmaverse-py, streamlining the data clinical workflow from database querying and complex data wrangling to the potential task of prepping data for regulatory Tables, Figures, and Listings (TFLs). Discover the 'delightful' Polars API and how its speed dramatically accelerates both exploratory and regid data tasks in pharmaceutical drug development. The workshop is led by Michael Chow, a Python developer at Posit who is a key contributor to open-source data tools, notably helping to launch the data presentation library Great Tables, and focusing on bringing efficient data analysis patterns to Python.