The ABRF Business Skills for Shared Research Resources (Cores) program is a hands-on experience to address the management aspects of operating a Core facility. The seemingly straightforward fee-for-service model used in most cores is a sophisticated integration of science and business. This includes how to: - recognize the value of your customer - evaluate the performance of a Core - define how a Core is managed to its maximum potential Core Facilities are born out of scientific need, but they are also driven by compliance and Uniform Guidance set forth by the Federal Government. Even though these two entities work in tandem, there often is a gap in understanding the relationship between science and business by the scientists and administrators of core facilities. Through instruction and group exercises, the Business Skills workshop provides attendees with the tools to more effectively communicate and understand the needs and the requirements of Core facilities best business practices, creating a mutually beneficial relationship between Science and Business within the research enterprise.