Synergic Entanglements between Structural Biology and Machine Learning (SESBML 2026) is an international conference hosted by the University of Malta from 13 to 15 May 2026. The event explores the cutting-edge integration of AI and machine learning with classical structural biology, highlighting topics such as macromolecular structure prediction, AI-driven drug design, cryo-EM, nucleic acid structure, protein dynamics, and advanced biophysical computing. Across three days, attendees take part in plenary lectures, technical sessions, flash presentations, poster discussions, and panel conversations with leading voices in the field. SESBML 2026 brings together researchers, structural biologists, bioinformaticians, data scientists, computer scientists, and MSc/PhD students working at the intersection of computational biology, biophysics, and AI-driven life sciences.