Children with mild to borderline intellectual disabilities (MBID) have problems with adaptive functioning in social situations and in peer relations. They are less accepted or even rejected by peers and have problems building social relations (Freeman, 2000, Gresham and MacMillan, 1997, Gresham et al., 1996, Guralnick, 1997, Hall et al., 2005, Maughan et al., 1999). Autistic Spectrum Disorder (ASD) includes a heterogeneous group of complex neurodevelopment disorders (dyslexia, ADHD and dyscalculia) which are associated with disturbed redox homeostasis. These neurodevelopment disorders are due to an interplay of factors affecting certain neural circuits, oxidative stress, reactive oxygen species, neuroinflammation and mitochondrial dysfunction (80%). This 45 minute lecture will outline how mushroom nutrition in the form of Hericium erinaceus biomass (Hericium-MRL) can address the symptoms associated within this heterogeneous group of complex neurodevelopment conditions by addressing: -high reactive oxygen species (ROS) -neuroinflammation -mitochondrial dysfunction -oxidative stress